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KMID : 1123920170310060362
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Korean Journal of Oriental Physiology and Pathology
2017 Volume.31 No. 6 p.362 ~ p.366
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Inhibitory Effects of Banhasasim-tang Extracts on Cisplatin-induced Body Weight Decrease in Mouse Model
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Kim Ha-Rim
Kim Mi-Seong
Lee Young-Rae
Ryu Do-Gon
Lim Chan-Han
Kim Byung-Suk
Lee Guem-San
Kwon Kang-Beom
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Abstract
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In this study, Banhasasim-tang extracts (BSTE) have an inhibitory effects on cisplatin-induced decrease of body weights in two mouse model. Cisplatin is the most widely used anticancer drug for treatment of various cancer. However, cisplatin treatment to cancer patients leads to many side effects such as nausea, vomiting and body weight decrease. BSTE has been used to decrease digestive disorders in South Korea. We hypothesize that BSTE improve the cisplatin-induced side effects in mouse models. We found that pre- and co-administration of BSTE inhibited decreases of body weights and food intake by cisplatin in mouse models. But BSTE had no synergistic effects for tumor shrinkage by cisplatin in xenograft model. Collectively, our data suggest that BSTE have great potential as a agent for having decrease effects on side effects by cisplatin in cancer patients.
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KEYWORD
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Banhasasim-tang, Cisplatin, Side effect, Body weight, Food intake
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